Benzoxazolon-5-arsonic acid



Patented June 23, 1925.

UNITED ,STATES PATENT OFFICE.

LUD WIG BENDA, OF MAINKUR, NEAR FRANKFORT-ON-THE-MAIN, GERMANY, ,AS-

SIGNOR TO LEOPOLD CASSELLA & CO. GESELLSCHAFT MIT BES TUNG, A CORPORATION O'F GERMANY.

BENZOXAZOLO NJ-ARSONIC ACID.

No Drawing. v

To all whom it may concern Be it known that I,.LUowIo BENDA, a citizen of the Swiss Confederation, residing at Mainkur, near Frankfort-on-the-Main, Germany, have invented a Benzoxazolon-5-Arsonic Acid, of which the following is a full description.

It has been found, that'by the action of Phosgen on 4-amino-3-hydrox phenyl-l-arsonic acid (Benda,-B. B. 44,35 8/1911) and its analogues and homologues, benzoxazolon- 5-arsonic acid is formed, possessing remarkably strong curative powers" in diseases caused by splrochaetae but also affording a 5 surprising prophylactic protection. Also on trypanos'omes, the new compound, which owing to its relative non-toxicity may beadvministered in proportionately large doses, both parenterally and ad 0s, exercises an Ewampl.500 g 4-amino-3-hydroxyphenylarsonic acid are dissolved at 70-80 in a solution of sodium acetate double-normal.

After cooling down, phosgen is intro- Application filed April 17, 1924. Serial No. 707,304.

duced into the solution at ordinary tempera ture until the latter shows a strong mineral acid reaction. The new arsenic compound, which in the main precipitates in the form of a crystalline paste, the mother liquor is sucked off and the crystalline mass is then Washed, first with cold water, and then with alcohol and ether. By recrystallizingfrom CHRANKTER HAF- hot water with the addition of some animal 7 charcoal, white crystals are obtained.

I claim: 1 v. As new product enzoxazolon-5-arsonic acid of the probable formula NH-CO N=COH AS03113 i AS63111 which is a colorless crystalline substance,

cohol, unsoluble in ether, easily soluble in alkalies at a low temperature.

In witness whereof I have hereunto signed my name this 4th day of April 1924.

LUDWIG BEND-A. \Vitnesses:

GABRIEL!) FLESCH,

JANE GLUoH. 

